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Medical Disinfection Information


Comparison of the effect of phthalaldehyde and glutaraldehyde on killing bacterial spores

Since o-phthalaldehyde (OPA) has been certified as a high-level disinfectant by the US Food and Drug Administration (FDA), it has been used for disinfection of endoscopes in foreign countries [1], and has been of great interest in China in recent years [~. In order to understand the ability of o-formaldehyde disinfectants to kill spores, we selected an imported o-formaldehyde disinfectant and a domestically produced strong glutaraldehyde disinfectant for comparison, and used a carrier-quantitative bactericidal assay to observe their efficacy in killing the spores of Bacillus subtilis black variant in the laboratory, and their stability in use. The results are reported below.

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2022/09/27

Discussion on the scheme of removing residual o-phthalaldehyde in endoscopy

Orthophthalaldehyde (OPA) has been widely used in recent years as a second-generation endoscopic disinfectant due to its low irritant odour and short disinfection time, and the current use rate of OPA is 45% in Japan and 41% in the United States [1]. However, o-phthalaldehyde has been banned for cystoscopy disinfection because of its allergenicity, and the residual OPA can damage the gastrointestinal mucosa of patients [2], leading to isopropyl alcohol shock reaction [3]. Although existing national and international guidelines on endoscopy emphasise the role of cleaning steps in the removal of disinfectant residues [4], there are no studies on the amount of OPA residues in actual endoscopes and the methods of effective removal. Therefore, the present study was conducted to verify the residual amount of OPA after different cleaning times and methods, with the aim of providing a theoretical basis for the development and application of clinical standards.

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2022/09/05

Observation on Application Effect of Multi-enzyme Cleaning Agent in Supply Room

[Abstract] Objective To study and analyze the application effect of multi-enzyme cleaning agent in the supply room. Methods From February 2016 to June 2016, 200 pieces of medical devices to be treated in the supply room of the Second People's Hospital of Shaanxi Province were selected as the research objects, and they were randomly divided into the control group and the experimental group, with 100 pieces in each group. The control group was cleaned with traditional cleaning agent, 1/200 configuration cleaning liquid, the experimental group was cleaned with multi-enzyme cleaning agent, 1/200 configuration, water temperature 25 ℃ ~ 30 ℃, the instrument shaft section was opened, the inner needle was removed, and soaked in the solution. Comparative analysis of experimental group and control group equipment visual inspection pass rate and Jieli test paper test pass rate. Results After the corresponding cleaning method, the number of unqualified pieces of visual inspection in the experimental group was 2 pieces, the number of qualified pieces was 98 pieces, and the qualified rate was 98.0 percent. In the control group, the number of unqualified visual inspection was 21, the number of qualified pieces was 79, and the qualified rate was 79.0%. The qualified rate of visual inspection in the control group was 79.0%, which was significantly lower than that of the experimental group, which was 98.0%. In the inspection of Jieli test paper, the number of qualified pieces in the experimental group was 97, and the number of unqualified pieces was 3, with a qualified rate of 97.0. In the control group, the number of qualified pieces was 75, the number of unqualified pieces was 25, the qualified rate was 75.0%, the difference between the two groups was statistically significant (P<0.05). Conclusion The application effect of multi-enzyme cleaning agent in the supply room is ideal, and the application of multi-enzyme cleaning agent can significantly improve the cleaning quality, easy to operate, and has the significance of clinical promotion.

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2022/04/19

Observation on the cleaning effect of multi-enzyme cleaning agent on oral instruments

To improve the cleaning method of multi-enzyme cleaning agent and improve the cleaning quality of oral cleaning instruments, 2,970 pieces of tooth extraction instruments with serious pollution were divided into 1 485 pieces in the test group and 1 485 pieces in the control group, and then divided into 3 groups with 495 pieces in each group, which were cleaned at 0 h, 1 h and 2 h after pollution respectively. The test group used 1:1 Multi-enzyme cleaning agent was heated to 25 ℃ and 40 ℃ with ultrasonic cleaning machine for 5 min. The control group was soaked with 1:1 multi-enzyme cleaning agent for 30 min. The two groups of tooth extraction instruments were taken out respectively and washed with flowing water. The residual occult blood detection method was used to detect the pilami hole, and the cleaning effect of each group was compared. Results The qualified rate of the test group and the control group which were cleaned immediately after pollution was 1%. The cleaning pass rate of the test group cleaned 1 h after contamination was 99-6%, and that of the control group was 97-0%, with a significant difference between the two (P <0-01). The clean pass rate of the test group cleaned 2 h after pollution was 99-0%, and the clean pass rate of the control group was 99-0%. 1%, there was a significant difference between the two (P <0.01). Conclusion For the heavily contaminated tooth extraction instruments, the effect of ultrasonic cleaning by heating 25 ℃ and 40 ℃ with multi-enzyme cleaning agent is remarkable.

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2022/04/04

What are the effects of storage time on the use of medical multi-enzyme cleaning fluids?

The multi-enzyme cleaning agent has good cleaning quality for the equipment, which is also based on the presence of enzymes, such as protease quickly decomposing protein stains, lipase quickly decomposing grease stains, and carbohydrase quickly decomposing carbohydrate stains.

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2022/03/21

Observation of the effect of multi-enzyme cleaning agent on the cleaning of thousands of batches of instruments

To explore the effect of multi-enzyme cleaning agent on batch instrument cleaning. Methods All kinds of contaminated medical devices were randomly divided into experimental group and control group. The control group was cleaned with traditional cleaning agent, and the experimental group was cleaned with multi-enzyme cleaning agent. Results The qualified rate of multi-enzyme cleaning equipment was 99. 07%, and the qualified rate of chlorine disinfectant cleaning equipment was 69. 68%. Conclusion The use of multi-enzyme cleaning agent after cleaning a batch of instruments without any residual substances, smooth appearance and non-toxic especially corrosive, save trouble and effort.

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2022/03/14

The process of multi-enzyme endoscopic decontamination

Main ingredients: contains protease, lipase, amylase, cellulase and other enzymes and degradable surfactants.

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2022/03/01

Observation on the cleaning effect of multi-enzyme cleaning liquid on the "blind area" of gastroscope cleaning

To explore the cleaning method of gastroscope cleaning "blind area", to ensure the effect of endoscopic cleaning and disinfection. Methods 60 cases of contaminated electronic gastroscope after diagnosis and treatment were divided into control group and observation group according to random number method. Control group: The contaminated endoscopes were cleaned and disinfected according to the 2004 edition of "Technical Operation Specification for Cleaning and Disinfection of Endoscopes. Observation group: on the basis of enzyme washing, gauze dipped in diluted multi-enzyme lotion (1: 150) was used to repeatedly scrub the cleaning "blind area" of gastroscope (operation part, clamp opening, apex part, suction and air supply and water supply opening). The two groups were sampled in the "blind area" after the end of the second wash, and the bacterial culture count and ATP bioluminescence method were used to detect the disinfection effect. Results The bacterial culture count and ATP bioluminescence reading values of the observation group were significantly lower than those of the control group (P <0.05). Conclusion The use of multi-enzyme cleaning liquid to repeatedly wipe the "blind area" of gastroscope cleaning can significantly improve the quality of endoscopic cleaning and disinfection, and ensure the effect of endoscopic cleaning and disinfection.

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2022/02/21

The role of multiple enzymes

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2022/02/15

How to choose the multi-enzyme cleaning solution

Multi-enzyme cleaning fluid is currently widely used for cleaning of hospital reusable instruments, such as endoscopes, scalpels, surgical forceps, etc.

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2022/02/11

Comparison of o-phthalaldehyde and glutaraldehyde

Ortho-phthalaldehyde, glutaraldehyde, peracetic acid, chlorine dioxide, acidic chlorinated electrolyzed water, etc. can be used for high-level disinfection of flexible endoscopes; sterilization equipment or peracetic acid, glutaraldehyde, etc. can be used for sterilization of flexible endoscopes.

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2021/11/29

Disinfection mechanism and characteristics of o-phthalaldehyde disinfectant

Phthalaldehyde, is an important pharmaceutical and chemical intermediates, previously mainly used for amine alkaloids, histamine fluorometer reagents and pharmaceutical testing. Since it was used for endoscopic disinfection in 1994 and found that it has a good disinfection effect, many studies have been carried out on the disinfection of o-phthalaldehyde abroad, and it has been developed into a new type of efficient disinfectant and passed the US FDA certification. Compared with the disinfectant glutaraldehyde (GTA), o-phthalaldehyde has the advantages of broad-spectrum, high efficiency and low corrosion, and also has its own characteristics of low irritation and low use concentration. In addition, o-phthalaldehyde also has a good killing effect on glutaraldehyde-resistant mycobacteria isolated in recent years. Therefore, o-phthalaldehyde has the potential to be a substitute for glutaraldehyde.

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2021/11/02

The scope of use of multi-enzyme cleaning fluid

The main cleaning principle of multi-enzyme cleaning agent is to decompose the macromolecular water-insoluble pollutants into small molecules and water-soluble substances through the decomposition of enzymes, so as to achieve the purpose of cleaning.

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2021/10/26

Clinical Common Problems


To Explore the Effect of Phthalaldehyde on Digestive Endoscope Simulation Field Disinfection

Objective To study and analyze the anti-virus sterilization effect of phthalaldehyde (OPA) on digestive endoscopy simulation site. Methods The suspension sterilization test method and the simulated field disinfection test were used. Methods, the anti-virus effect of phthalaldehyde on digestive endoscopy was observed and analyzed. Results The content of ortho-phthalaldehyde in ortho-phthalaldehyde disinfectant was 5500 mg/L. The neighborhood. The concentration of the original solution of the benzene aldehyde disinfection solution was 2500 mg/L to kill the Escherichia coli, Pseudomonas aeruginosa and Staphylococcus in the suspension for three minutes, and the killing value was more than 5.0. Neighbor Candida albicans and Mycobacterium chelonae subspecies abscess in suspension were killed for three minutes at a concentration of 2800 mg/L in the benzene-formaldehyde disinfectant, with a killing logarithm of> 4.0. Right. The number of inactivation pairs of poliovirus in the suspension was> 4.0. The ortho-phthalaldehyde stock solution concentration of 5500 mg/L disinfectant, in the digestive endoscope for 20 minutes, the digestive The killing of Pseudomonas aeruginosa in the lumen of the mirror simulation was> 5.0. Conclusion o-phthalaldehyde disinfectant can kill bacteria and viruses in suspension quickly and effectively, digestive endoscopy simulation The effect of field disinfection is good.


2022/12/20

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06

2022-12

Effect of o-phthalaldehyde on disinfection of contaminated hepatitis B virus gastroscope and its effect on HBV-DNA content

[Abstract] Objective To study and analyze the disinfection effect of phthalaldehyde on contaminated hepatitis B virus gastroscope and the deoxygenation of hepatitis B virus Sugar nucleic acid (HBV-DNA) content affects the effect. Methods 168 cases of patients with viral hepatitis B after the use of 168 sets of gastroscope, using the computer Randomly selected methods were divided into study group and control group, each 84 sets. The control group was treated with enhanced glutaraldehyde immersion disinfection, while the study group was treated with phthalate Formaldehyde disinfection, and the two groups before and after cleaning and disinfection of 3, 5rain of the gastroscope cavity polymerase chain reaction PCR fluorescence quantitative and qualitative detection. The average content of HBV-DNA was compared. Results Two groups before and after cleaning and disinfection 3min gastroscope cavity PCR fluorescence quantitative and qualitative examination The difference in the content of HBV-DNA was not statistically significant (corpse s................................................................................................................ The average content of sex detection HBV-DNA (5.89±0.28)× 10, (5.32±1.28)X10 was significantly lower than that of the control group (8.34±0.65)X10, (8.34±1.36)X10, the difference is statistically significant <0.o5). Conclusion The use of o-phthalaldehyde for the elimination of contaminated hepatitis B virus gastroscopy. disinfection effect is better, can effectively reduce the HBV-DNA content, worthy of clinical application.


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2022-09

Effect of o-phthalaldehyde on gastroscope disinfection in patients with hepatitis B virus infection

Objective To investigate the effect of phthalaldehyde on gastroscope disinfection in patients with hepatitis B virus infection. Methods 218 patients with HBV infection and undergoing gastroscopy admitted to the hospital from May 2014 to May 2017 were selected as the research objects, and 218 gastroscopes were collected. According to the different cleaning methods of gastroscopes after examination, they were divided into o-phthalaldehyde group and enhanced glutaraldehyde group, with 109 gastroscope surface and gastroscope cavity specimens collected before, after cleaning and after disinfection, and RT- PCR was used to detect HBV-DNA load. Results After cleaning, the clearance rates of gastroscope surface and gastroscope cavity in phthalaldehyde group were 99 5.0% and 99 9.9%, respectively, and those in glutaraldehyde group were 99 6.4% and 99 9.9%, respectively. There was no significant difference in the clearance rates of gastroscope surface and gastroscope cavity between the two groups (P <0.05). After disinfection, the surface clearance rate of gastroscope in phthalaldehyde group was 93 .23%, which was higher than that in glutaraldehyde group (87 .01%) (P <0.05). The clearance rate of gastroscope in both groups was 100 .00%. Conclusion Using phthalaldehyde to disinfect the gastroscope of HBV patients after use, the disinfection effect is better than that of enhanced glutaraldehyde disinfection, the action time is shorter, and it has the potential to replace the enhanced glutaraldehyde.


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