To Explore the Effect of Phthalaldehyde on Digestive Endoscope Simulation Field Disinfection

Objective To study and analyze the anti-virus sterilization effect of phthalaldehyde (OPA) on digestive endoscopy simulation site. Methods The suspension sterilization test method and the simulated field disinfection test were used. Methods, the anti-virus effect of phthalaldehyde on digestive endoscopy was observed and analyzed. Results The content of ortho-phthalaldehyde in ortho-phthalaldehyde disinfectant was 5500 mg/L. The neighborhood. The concentration of the original solution of the benzene aldehyde disinfection solution was 2500 mg/L to kill the Escherichia coli, Pseudomonas aeruginosa and Staphylococcus in the suspension for three minutes, and the killing value was more than 5.0. Neighbor Candida albicans and Mycobacterium chelonae subspecies abscess in suspension were killed for three minutes at a concentration of 2800 mg/L in the benzene-formaldehyde disinfectant, with a killing logarithm of> 4.0. Right. The number of inactivation pairs of poliovirus in the suspension was> 4.0. The ortho-phthalaldehyde stock solution concentration of 5500 mg/L disinfectant, in the digestive endoscope for 20 minutes, the digestive The killing of Pseudomonas aeruginosa in the lumen of the mirror simulation was> 5.0. Conclusion o-phthalaldehyde disinfectant can kill bacteria and viruses in suspension quickly and effectively, digestive endoscopy simulation The effect of field disinfection is good.

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Effect of o-phthalaldehyde on disinfection of contaminated hepatitis B virus gastroscope and its effect on HBV-DNA content

[Abstract] Objective To study and analyze the disinfection effect of phthalaldehyde on contaminated hepatitis B virus gastroscope and the deoxygenation of hepatitis B virus Sugar nucleic acid (HBV-DNA) content affects the effect. Methods 168 cases of patients with viral hepatitis B after the use of 168 sets of gastroscope, using the computer Randomly selected methods were divided into study group and control group, each 84 sets. The control group was treated with enhanced glutaraldehyde immersion disinfection, while the study group was treated with phthalate Formaldehyde disinfection, and the two groups before and after cleaning and disinfection of 3, 5rain of the gastroscope cavity polymerase chain reaction PCR fluorescence quantitative and qualitative detection. The average content of HBV-DNA was compared. Results Two groups before and after cleaning and disinfection 3min gastroscope cavity PCR fluorescence quantitative and qualitative examination The difference in the content of HBV-DNA was not statistically significant (corpse s................................................................................................................ The average content of sex detection HBV-DNA (5.89±0.28)× 10, (5.32±1.28)X10 was significantly lower than that of the control group (8.34±0.65)X10, (8.34±1.36)X10, the difference is statistically significant <0.o5). Conclusion The use of o-phthalaldehyde for the elimination of contaminated hepatitis B virus gastroscopy. disinfection effect is better, can effectively reduce the HBV-DNA content, worthy of clinical application.

Observation on the effect of multi-enzyme cleaning agent for batch instrument cleaning

Abstract: Objective To investigate the cleaning effect of multi-enzyme cleaning agent on batch instruments. Methods All kinds of contaminated medical devices were randomly divided into experimental group and control group. According to the group using the traditional cleaning agent cleaning, the experimental group using multi enzyme cleaning agent cleaning. Results The qualified rate of multi-enzyme cleaning batch instruments was 99.07%. Chlorine The qualified rate of disinfectant cleaning batch instruments was 69.68%. Conclusion There is no residual substance after using multi-enzyme cleaning agent to clean the batch of instruments, and the appearance is smooth. And non-toxic non-corrosive, save trouble and effort.

Comparative study of ortho-phthalaldehyde and glutaraldehyde for endoscopic disinfection

[Abstract] Objective To study the clinical application effect of o-phthalaldehyde and glutaraldehyde in endoscopic disinfection. Methods from September 2011 to March 2015 After monthly endoscopic examination, 80 cases of endoscopes were divided into different disinfection treatment groups, group A underwent phthalaldehyde disinfection, group B underwent glutaraldehyde disinfection, each. In 40 cases, the effect was evaluated after disinfection treatment. Results The qualified rate of two groups of endoscopes after disinfection treatment was 1 0 0.0%, and the difference was not statistically significant (P> 0.05). However, the clinical work efficiency (appointment time, total disinfection) and endoscopic disinfection time of group A were better than those of group B, and the difference was statistically significant (P <0.05). knot The clinical use of phthalaldehyde to disinfect endoscopes has a significant effect, which can shorten the disinfection time and reduce toxicity, and is worth using.

Evaluation of Disinfection Effect of Phthalaldehyde Disinfectant on Medical Instruments

Abstract: OBJECTIVE To evaluate the disinfection effect of orthophthalaldehyde disinfectant on medical instruments. Methods According to the "Disinfection Technical Specifications (2002 Edition)", the carrier quantitative killing Bacteria test and simulated field test to evaluate the disinfection effect. As a result, the effect of o-phthalaldehyde disinfection solution for 6 hours on Bacillus subtilis black variant spores stained on stainless steel sheets. The killing logarithm value is> 3.00; After 7h of action, the killing logarithm value of Bacillus subtilis var. noir spores stained on the teeth of hemostatic forceps is> 3.00. Conclusion o-phthalaldehyde disinfectant is very important for medical treatment. The disinfection effect of medical instruments is better.


To observe the disinfection performance of a compound o-phthalaldehyde disinfectant. Methods Using the carrier quantitative and qualitative bactericidal test method, the compound o-benzene. The germicidal efficacy of the two aldehyde disinfectant was tested and its toxicity was evaluated by animal experimental methods. Results The compound containing 5.7g/L o-phthalaldehyde was used. The disinfectant acts on the spores of Bacillus subtilis var. niger on the stainless steel carrier for 60min, with an average killing logarithm value of> 5.0. After acting for 120min, complete killing can be achieved. The compound phthalaldehyde disinfectant on mice acute oral toxicity test LD. Values> 5000mr,/kg body weight, mouse bone marrow polychromatic erythrocytes were negative. The phthalaldehyde disinfectant stock solution was sealed and packaged, and stored at 54 ~ C constant temperature for 14 days, and its content reduction rate was 8.72. Conclusion The compound phthalaldehyde elimination The poison has good effect on killing bacterial spores, belongs to non-toxic substances, and has stable storage performance.

Toxicological study of an o-phthalaldehyde disinfectant

To evaluate the safety and application value of an o-phthalaldehyde disinfectant (CidexOPA). Methods Different doses of the o-phthalaldehyde disinfectant (OPA) were used for acute oral toxicity test in mice, and the poisoning performance and death of mice in each group were observed and compared. Different doses of OPA and glutaraldehyde were used for micronucleus test of bone marrow polychromatic erythrocytes in mice, and the biological safety between OPA and glutaraldehyde was compared. Results The median lethal dose (LD) of CidexOPA to mice was> 6500mr,/kg (body weight). There was no difference in PCE micronucleus rate between the CidexOPA group and the glutaraldehyde group. Conclusion CidexOPA is non-toxic and has high safety in clinical application.

Study on test paper for rapid detection of concentration of o-phthalaldehyde disinfectant

Abstract: Objective To prepare a rapid test strip for detecting the concentration of ortho-phthalaldehyde (OPA) disinfectant. method adopted on Compared with the color of the test paper, the various factors affecting the color reaction of the test paper are studied. Results Na2 SO3, glycine, The concentration of KH2PO4 and methylene blue were 8, 80, 40 and 0. 04 g /L respectively, and the detection time was 2 min, the effect was the best. The addition of KH2PO4 can greatly Improve the color rate; the test paper dyed blue substrate is more conducive to the identification of color. Conclusion The prepared test paper has a good detection effect on unilateral OPA products. and test paper stability, good reproducibility. The method is simple, fast and feasible.

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