The experiment clearly confirmed for the first time! Two alcohol hand sanitizers recommended by WHO can inactivate the new coronavirus
Release time:
2020-03-27
In the current grim situation of the COVID-19 epidemic, effective health measures are essential to prevent the spread of the virus. People around the world have snapped up a variety of masks, disinfectants, alcohol ...... However, on the market a variety of "sterilization hand sanitizer", "disinfection hand sanitizer" is not necessarily effective against the new crown virus.
Earlier, it was reported that many of the best-selling styles did not kill the new coronavirus, despite the rapid rise in sales of most of the products on the e-commerce platform.
Among them, the plant extract as the main component of hand sanitizer can not kill the new crown virus, the main chlorhexidine disinfectant is ineffective against the virus, benzalkonium chloride components can kill the virus, but the effect of the new crown virus is unknown.
Therefore, it is necessary to evaluate current infection control strategies against COVID-19 viruses. The sixth edition of the trial of the diagnosis and treatment plan issued by the National Health Commission clearly mentions that ether, 75% ethanol, chlorine-containing disinfectant, peracetic acid and chloroform and other lipid solvents can effectively inactivate the virus.
And recently, researchers in a paper published in biorxiv.org have been hands-on, demonstrating for the first time that a WHO-recommended disinfectant can inactivate the new coronavirus and determining the effectiveness of a strategy to use disinfectants to ensure hand hygiene.
The World Health Organization's Guidelines for Hand Hygiene in Health Care recommends the use of two alcohol-based hand sanitizers to reduce infection and spread of pathogens.
These recommendations are based on rapid action and broad spectrum bactericidal activity, as well as easy availability and safety.
Previous studies have shown that WHO formulations I and II disinfecting solutions are capable of inactivating closely related SARS-CoV and MERS-CoV6.
So far, recommendations for inactivating SARS-CoV-2 have only been made from the results of studies of other coronaviruses.
To assess whether alcohol-based disinfectants are also effective in inactivating SARS-CoV-2, the researchers tested different concentrations of WHO Formulations I and II, as well as the alcohols ethanol and 2-propanol, for antiviral activity.
(Figure 1: Inactivating virus activity of WHO formulations I(85% ethanol) and II(75% isopropanol) against SARS-CoV-2.)
WHO Formulation I is based on 85% ethanol, highly effective in inactivating virus, with reduced factors (RFs) of £ 5.9, and concentrations between 40% and 80%.
Regression analysis showed a comparison with SARS-CoV, MERS-CoV, and bovine CoV (BCoV), which is often used as a surrogate for highly pathogenic human CoV (FIG. 1A).
WHO formula II, based on 75% isopropanol, showed better antiviral effect at low concentration, with complete virus inactivation, with RFs of £ 5 at the lowest concentration of 30% (Figure 1B).
Regression analysis showed that the inactivation profile of SARS-CoV-2 was between SARS-CoV, BCoV and MERS-CoV (FIG. 1B).
Next, the researchers discussed SARS-CoV-2 susceptibility to individual ingredients of WHO-recommended formulations that are also the main ingredients of commercially available hand sanitizers.
Both alcohols, ethanol (Figure 2A) and 2-propanol (Figure 2B), were able to reduce the virus titer to background levels within 30 seconds, with RFs between 4.8 and 5.9 after 30 seconds.
The results of the study showed that both WHO formulations were effective in inactivating SARS-CoV-2.
Notably, both ethanol and 2-propanol were effective in inactivating the virus within 30 seconds at a minimum final concentration of at least 30%.
Alcohol is the basis for hand disinfection that is often used in many health care facilities. Therefore, the results of this study are essential to minimize virus transmission and maximize virus inactivation in the current outbreak.
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