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Hospital infection, hand is the main "means of transport" carrying pathogenic microorganisms, is a well-deserved "culprit hand". Pay attention to hand hygiene is the most economical and effective way to control hospital infection and reduce the spread of epidemic contact.

During the epidemic, with the unprecedented attention paid to personal health, further spawned the popularization and application of hand disinfectants, greatly improving the effectiveness and compliance of hand hygiene. The World Health Organization (WHO) and the United States Centers for Disease Control and Prevention (CDC) hand hygiene guidelines recommend the use of alcohol-based hand disinfectants. Alcohol-containing hand disinfectants act quickly, are easy to use, and can effectively kill a variety of bacteria, fungi and enveloped viruses. It is currently the most common alcohol disinfectant used by medical institutions and community families. According to the medical literature and expert lectures at home and abroad, alcohol-containing hand disinfectants have limited inactivation effect on non-enveloped viruses.

Does the virus have a cell membrane? What is the cell membrane?is actually inViruscore shellThe outside is covered with a layer to protect its activity.Protein. Generally speaking, enveloped viruses are more likely to be "killed", while non enveloped viruses such as polio virus (PV), coxsackie virus, ECV and new enteroviruses are more difficult to kill. The method of evaluating the inactivation of virus by disinfectants in China is based on the 2002 edition of "Disinfection Technical Specification". According to the specification, the virus required to be detected is poliovirus type 1 (PV-1), and the evaluation standard is the average inactivation logarithm of 3 tests ≥ 4.00. The experimental system is 0.1ml organic interfering substance +0.1ml virus suspension +0.8ml disinfectant to be tested. The ratio of disinfectant in the experimental system should reach 80%, I .e. the concentration of disinfectant in the experimental system is 80% of the detection concentration. Polio virus is a non-enveloped enterovirus, because it represents the most resistant strain of virus microorganisms, it is often used as a disinfectant inactivation virus indicator in domestic and foreign standards.

One study showed that hand disinfectants that can inactivate viruses can either increase the alcohol concentration of the disinfectant or add acidic substances to the alcohol solution. Like 70%(V/V) ethanol + citric acid compound disinfectant for 30 seconds, the inactivation logarithm of PV1 is close to 3. However, adding 0.1 hydrogen peroxide to the same concentration of ethanol can also effectively kill PV1.

Another study evaluated the use of a gel-type ethanol 85%(W/W) hand disinfectant with a PV1 inactivation logarithm> 4 for 3 minutes under acidic conditions, with a total of 96 health care workers from France and London receiving questionnaires for 4 weeks of continuous use, and 94.8 per cent of them considered the product to be non-viscous and acceptable; 89.6 per cent of the staff thought that repeated use had no effect on the skin and felt good; 91.6 per cent thought that the product smelled good and acceptable; and 65.6 per cent thought that the new gel product was better than the previous hand disinfection.

Hand disinfectant virus inactivation program I.

Ethanol hydrogen peroxide compound (Pulejie wash-free surgical hand disinfectant)

Ethanol, content 72%-82%(V/V), hydrogen peroxide, content 0.10-0.14 (W/V). The PH value (25 ℃) is 3.05, the action time is 0.5min, 1min and 1.5min respectively. The test is repeated 3 times. The average inactivation logarithm values for poliovirus are 4.04, 4.11 and 4.31 respectively, which all meet the standard requirements of "Disinfection Technical Specification" (2002 Edition) 2.1.1.10.7 (average inactivation logarithm value ≥ 4.00).

Hands Disinfectant Virus Inactivation Protocol II

Ethanol gel (ANNJET Ansett Wash-Free Surgical Hand Disinfectant)

Content 75%-85%(V/V), and specially added moisturizing and emollient ingredients. The PH value (25 ℃) is 3.12, the action time of polio inactivation experiment is 0.5min, 1min and 1.5min respectively, and the experiment is repeated three times. The average inactivation logarithm values for polio virus are 4.02, 4.17 and 4.42 in turn, all of which meet the standard requirements of "Disinfection Technical Specification" (2002 Edition) 2.1.1.10.7 (average inactivation logarithm value ≥ 4.00).

In summary, the above two schemes can efficiently inactivate poliovirus (non-enveloped virus, the most resistant strain of the virus microorganism represented, as a disinfectant inactivation virus indicator) for 1min. The new crown virus belongs to the category of enveloped viruses, hand disinfection.The virus is more likely to be"Kill"!